Prohibited List 2025

Prohibited List 2025 Advisory Note

WADA recently released the 2025 WADA Prohibited List, which will come into effect on January 1, 2025. The 2025 List includes changes that athletes and athlete support personnel should be aware of. The full published prohibited list can be found here - https://www.wada-ama.org/sites/default/files/2024-09/2025list_en_final_…

Below is a summary of the key modifications and clarifications.

S3. Beta-2 Agonists – Inhaled Formoterol

The maximum total daily dose of inhaled formoterol (54 micrograms over 24 hours) remains unchanged. However, from 2025, athletes can only inhale a maximum of 36 micrograms over any 12-hour period before a Therapeutic Use Exemption is required.. There are no changes to the exceptions currently in place for inhaled salbutamol, salmeterol and vilanterol and beta-2 agonists used by all other routes of administration are prohibited at all times. 

M1. Manipulation of Blood - Removal of Apheresis (plasma donation) as a Prohibited Method

The donation of blood or plasma components will no longer be prohibited when performed at an accredited collection centre.  WADA has clarified that this includes blood donation by apheresis which is the medical technology that separates the blood components and returns some of the component back to the donor. Athletes should be aware that documentation of the procedure from a legitimate and accredited donation centre must be available if requested by anti-doping authorities.

New examples, clarifications and additional substances added to the Prohibited List:

S4. Hormone and Metabolic Modulators.

Elacestrant. Added as an example of a prohibited substance prohibited substance and is available as an anti-oestrogen medication.

MOTS-c. Added as a prohibited substance. MOTS-c is an experimental AMP-activated protein kinase activator which is often marketed in wellness settings and on social media as a weight loss peptide. 

S519 and S597: Added as examples of prohibited insulin-mimetics.

S5. Diuretics and Masking Agents.

Xipamide. Added as an example of a prohibited substance.

S6. Stimulants.

Midodrine. Added as an example of a prohibited stimulant and is prescribed in Ireland to treat hypotension. 

Tesofensine. Added as a prohibited stimulant. Tesofensine is more commonly appearing in the ingredients of supplements especially for weight loss. 

Guanfacine. Clarified as a permitted substance and is prescribed as an ADHD treatment. 

Beta-Blockers

Ski and Snowboard Disciplines.

Beta-blockers are no longer prohibited in any skiing or snowboarding events.

Monitoring Program for 2025

WADA has updated the Monitoring Program, listing substances not currently on the Prohibited List but under evaluation for potential misuse. This includes substances marketed in supplements or emerging therapeutic agents. 

Important Athlete Responsibilities

Stay Informed.

Use resources such as the WADA Prohibited List and MedCheck to verify medications and supplements.

Verify Supplements.

Only use supplements tested by batch-testing programs like Informed-Sport.

Seek Guidance.

Consult medical professionals or anti-doping officers if unsure about a substance or method.

The 2025 Summary of Major Modifications and Explanatory Notes should be read to familiarise yourself with the changes - https://www.wada-ama.org/sites/default/files/2024-09/2025_list_explanat…

Frequently asked questions regarding the Prohibited List can be found through the following link - https://www.wada-ama.org/en/prohibited-list